What do you do when you submit your manuscript or your screenplay to an editor or a producer and they give you feedback you don't agree with? Well, it depends.
* Are they just offering an opinion, with nothing else at stake? In that case, thank them politely, make a note of their reaction, and then ignore it--unless you find that several people give you similar feedback. In that case it might be worth revisiting the comments to double-check whether they could be right.
* Are they offering to buy it, conditional on you making the changes? If so, and if you don't feel that the changes would totally ruin the project, you should probably go ahead. Otherwise, you may lose the sale, or they may buy it and hire someone else to make the changes. You may feel that you can make the alterations more sensitively than someone else would. However, don't talk yourself into making changes that you know, in your heart, are wrong. I did it once, for a TV movie, and regretted it (and ultimately the movie wasn't made anyway).
Be sure you understand their reasoning for wanting the changes. If there is a problem, you may be able to find a more elegant solution that satisfies them and you, too.
Also worth keeping in mind is this rule: If they suggest something that makes the project better, make the change and be grateful; if they suggest something that is neither better nor worse, just different, make the change and shut up; if they suggest something that makes it worse--fight! Save your ammunition for the important battles, give way on the unimportant ones.