The Los Angeles Times featured an interview with actress/writer Tina Fey, who is responsible for my favourite current sitcom, “30 Rock” (even better than “Curb Your Enthusiasm”). Here’s what she said about combining comedy and drama:
“I almost feel like the two always have to be blended. You always want to have a story that people care about. It just makes telling the jokes so much easier, and likewise I wouldn't want to watch a drama where the characters have no sense of humor. There really almost isn't a division.”
(for tips on how to write what only you can write, see my book, "Your Writing Coach," published by Nicholas Brealey and available on Amazon and other online and offline retailers.)